Various Th1/Th2 ratios, including TNF-α/IL-10, TNF-α/IL-4, TNF-α/IL-5, IFN-γ/IL-4, and IL-12/IL-4, were significantly lower in the MPE of LCP than in the pleural effusion of HP (Figure 6H and sFigure 5A and 5B). This evidence concerns the gene IL4 and Pleural effusion.