Moreover, at each stage of the TEM transition, 14 genes (FOXO1, INPP4A, KLF12, KMT2C, MAP3K5, MLLT3, NEAT1, NFATC2, PRKY, RALGAPA1, RASA3, SYNE1, SYNE2, ZBTB20, and ZEB2) exhibited consistently higher expression levels in the TEM subpopulations of LCP patients compared to those in HP patients (Figure 4G). This evidence concerns the gene SYNE1 and Legg-Calve-Perthes disease.