Moreover, at each stage of the TEM transition, 14 genes (FOXO1, INPP4A, KLF12, KMT2C, MAP3K5, MLLT3, NEAT1, NFATC2, PRKY, RALGAPA1, RASA3, SYNE1, SYNE2, ZBTB20, and ZEB2) exhibited consistently higher expression levels in the TEM subpopulations of LCP patients compared to those in HP patients (Figure 4G). Here, RALGAPA1 is linked to Legg-Calve-Perthes disease.