Our previous research in lung cancer demonstrated that the immunosuppressive function of lipid-associated tumor-associated macrophages (LA-TAMs) played a crucial role in shaping the metastatic pleural microenvironment, with C5 identified as a predictive marker for survival in epithelial growth factor receptor (EGFR)-mutated lung cancer with MPE 15. The gene discussed is EGFR; the disease is lung carcinoma.