Moreover, at each stage of the TEM transition, 14 genes (FOXO1, INPP4A, KLF12, KMT2C, MAP3K5, MLLT3, NEAT1, NFATC2, PRKY, RALGAPA1, RASA3, SYNE1, SYNE2, ZBTB20, and ZEB2) exhibited consistently higher expression levels in the TEM subpopulations of LCP patients compared to those in HP patients (Figure 4G). The gene discussed is MAP3K5; the disease is Legg-Calve-Perthes disease.