Analysis of DEGs in Cycling GZMA and GZMA CD4 T cells from pleural effusion of HP and LCP revealed that seven transcription factors (MLLT3, KLF12, FOXP1, NFKB1, ZEB2, TOX, JAZF1) were upregulated in both cycling GZMA CD4 and GZMA CD4 cells in MPE of LCP (Figure 5H). The gene discussed is CD4; the disease is Legg-Calve-Perthes disease.