Analysis of DEGs in Cycling GZMA and GZMA CD4 T cells from pleural effusion of HP and LCP revealed that seven transcription factors (MLLT3, KLF12, FOXP1, NFKB1, ZEB2, TOX, JAZF1) were upregulated in both cycling GZMA CD4 and GZMA CD4 cells in MPE of LCP (Figure 5H). This evidence concerns the gene TOX and Legg-Calve-Perthes disease.