Notably, the numbers of common differentiation-induced gene expression changes between AD and healthy controls (Table 2; see numbers shared by HC M DIF/UD + PSEN1 DIF/UD and HC F DIF/UD + APOE4 DIF/UD) were as many as, or more than, the numbers of common differentiation-induced gene expression changes between EOAD and LOAD (Table 2; see numbers shared by PSEN1 DIF + APOE4 DIF) and between healthy controls (Table 2; see numbers shared by HC M DIF + HC F DIF). The gene discussed is APOE; the disease is Alzheimer disease.