CD71+ TANs in glioblastoma promote immunosuppression via lactate-driven histone lactylation and ARG1 upregulation 90; T3-TANs (marked by dcTRAIL-R1) in pancreatic cancer remodel vasculature through VEGFα secretion and accelerate tumor growth 91; CD10+ALPL+ TANs in hepatocellular carcinoma induce CD8+ T-cell exhaustion via NAMPT signaling 92; and RLSNs (Retnlg+Lcn2+ senescence-like neutrophils) in bladder cancer, impaired in ferroptosis, create a metastasis-promoting niche 93. This evidence concerns the gene ALPL and familial pancreatic carcinoma.