Genetic knockout of Dectin-1 significantly attenuated renal fibrosis induced by UUO or IR, primarily by suppressing macrophage infiltration via the Syk/NF-κB/CCL2-CCR2 axis and inhibiting MMT through the TGF-β/Smad pathway (Figure S11). The gene discussed is TGFB1; the disease is renal fibrosis.