Histology (H&E) detected a progressive renal fibrosis developed in all mouse models in wild-type (WT) mice induced by UUO, FA, and IR, which was associated with a marked upregulation of Clec7a as determined by real-time PCR at the mRNA level and by flow cytometry at the cellular levels (Figure 2A-I). Here, CLEC7A is linked to renal fibrosis.