Our data revealed amelioration of BTN3A1‐induced lupus‐like changes, such as improved degree of renal injuries and reduced percentage of CD3+, CD8+ T cells, Th1, Th2, Th17 cells, upregulated percentage of Treg cells, and lower expression of IL‐4, IL‐6, IL‐10, IL‐17A, IFN‐γ, TNF‐α, and dsDNA. Here, TNF is linked to systemic lupus erythematosus.