SLC1A5 and SLC3A2/SLC7A5 are essential channels on the NK cell membrane that regulate amino acid transport. The high expression of these transporters can, on the other hand, activate the downstream mTOR signaling pathway, thereby enhancing the metabolic capacity of NK cells within the tumor microenvironment. This metabolic enhancement supports the improved survival and antitumor activity of NK cells [101]. This evidence concerns the gene SLC7A5 and neoplasm.