Tumor cell recognition and killing by NK cells are largely driven by a repertoire of activating receptors, notably including NKG2D, NK receptor group 2, member C (NKG2C), DNAX‐accessory molecule‐1 (DNAM‐1), CD244 (also known as 2B4), and the natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 [15, 17]. Here, CD244 is linked to neoplasm.