IFNG and neoplasm: However, long‐term glucose metabolism inhibition not only progressive exhaust NK cell‐mediated antitumor activity, specifically manifested as reduced IFN‐γ secretion and impaired cytotoxic granule release, but also induces H3K27me3‐mediated epigenetic silencing, leading to the permanent shutdown of proliferation‐related genes, which results in a decline in proliferative capacity [64, 69], thereby resulting tumor progression or the failure of antitumor therapy.