CALR and neoplasm: They mediate cytotoxicity and tumor cell lysis through interactions with their respective ligands, such as human leukocyte antigen (HLA)‐B‐associated transcript 3/Bcl‐2‐associated athanogene 6 (BAT3/BAG6), mixed‐lineage leukemia 5 (MLL5), and ecto‐calreticulin (ecto‐CRT) [35, 36].