[94] found that the postoperative inflammatory environment in colorectal cancer induces a significant increase in myeloid‐derived suppressor cells (MDSCs), which heavily consume Arg in the TME by synthesizing and accumulating Arg1, leading to impaired proliferation, cytotoxicity, and IFN‐γ production of NK cells, ultimately promoting postoperative tumor metastasis. The gene discussed is IFNG; the disease is neoplasm.