They imply that RPE cellular impairment stems from chronic hyperglycemia‐induced glycolytic dysregulation, which fosters high lactic acid production, triggers histone lactylation of Txnip, activates the Txnip/Nlrp3 signaling cascade, and eventually instigates PANoptosis (Figure 8G). The gene discussed is NLRP3; the disease is Hyperglycemia.