The further ANOVA results showed that for the right MOG, there were significant differences among the three groups (F [2, 50] = 12.84, p  < 0.001, partial η2 = 0.33), with larger GMV of the anxiety (0.41 ± 0.04, p=0.031, Cohen's d = 1.00, 95%CI [0.012, 0.068]) and the control (0.44 ± 0.03, p  < 0.001, Cohen's d = 1.70, 95%CI [0.035, 0.085]) groups than the anxiety–depression comorbidity group (0.37 ± 0.04, Figure 1b). The gene discussed is MOG; the disease is depressive symptom measurement.