HCT116 (human-derived) and CT26 (mouse-derived) colon cancer cells exhibit distinct genomic backgrounds, which may involve different mutational profiles that influence KDM6B's regulatory mechanisms; KDM6B activity is sensitive to intracellular metabolic modifications27, and metabolic variations between the two cells may affect KDM6B-mediated gene regulation. This evidence concerns the gene KDM6B and malignant colon neoplasm.