Conclusion: KDM6B potentially suppresses CRC progression by enhancing CD8+ T cell infiltration via dual mechanisms: STAT3-mediated transcriptional activation and H3K27me3 demethylase-dependent epigenetic remodeling of PD-L1 and chemokine genes (CCL5/CXCL9/CXCL10). Here, KDM6B is linked to colorectal carcinoma.