Additionally, the HOTTIP single-nucleotide polymorphisms (SNPs) were indicated to be associated with cancer development and prognosis in various cancers such as breast cancer (BC) 22, colorectal cancer (CRC) 23, 24, gastric cancer (GC) 25, 26, gastrointestinal (GI) cancers 27, hepatocellular carcinoma (HCC) 28, lung cancer 29, neuroblastoma 30, and pancreatic cancer 31. The gene discussed is HOTTIP; the disease is cancer.