For the correlations of these risk factors to HOTTIP expression, a previous study has suggested that the lncRNAs HOTTIP was over expressed in extracellular vesicles (EVs) from smokers and NSCLC patients 40, and HOTTIP was found to be overexpressed in squamous cell carcinoma and in smokers 41. This evidence concerns the gene HOTTIP and non-small cell lung carcinoma.