Taken together, although the lncRNAs HOTTIP has demonstrated to be associated with oncogenic regulation in cancer progression in various cancers including oral cancer 7, 8, 15, 16, 19, 26-28, 41, and the HOTTIP rs3807598 and rs2067087 were suggested to be associated with cancer risk 24, 26. This evidence concerns the gene HOTTIP and lip and oral cavity carcinoma.