However, in HCC, the HOTTIP rs2067087 was suggested to be associated with increased HCC risk, while the HOTTIP rs3807598 variant genotype was found to show significantly longer survival time in HBV negative subgroup, and no significant associations between the HOTTIP rs3807598 and HCC risk was found in the same study 28. This evidence concerns the gene HOTTIP and hepatocellular carcinoma.