The analysis of GPR141 mRNA expression between paracancerous tissues and cancers revealed that GPR141 expressed significantly higher in BRCA (Breast invasive carcinoma), ESCA (Esophageal carcinoma), GBM (Glioblastoma multiforme), HNSC (Head and Neck squamous cell carcinoma), KIRC (Kidney renal clear cell carcinoma), KIRP (Kidney renal papillary cell carcinoma), STAD (Stomach adenocarcinoma), UCEC (Uterine Corpus Endometrial Carcinoma), and significantly lower in COAD (Colon adenocarcinoma), LUSC (Lung squamous cell carcinoma), PAAD (Pancreatic adenocarcinoma), READ (Rectum adenocarcinoma). This evidence concerns the gene GPR141 and carcinoma of esophagus.