However, chemerin interferes with the interaction of PTEN-CMKLR1 to upregulate the expression of phosphatase and tensin homolog (PTEN) and the activity of phosphatase, resulting in weakened PTEN ubiquitination and decreased phosphorylation of AKT (p-AKT), thus inhibiting the migration, invasion and metastasis of liver cancer cells 30. The gene discussed is RARRES2; the disease is liver cancer.