PLAU and Familial prostate cancer: Additionally, the infiltration of CD8+ T cells were decreased in prostate cancer compared to peritumoral tissues (Figures 1C, D, Supplementary Figure 1B), and the expression of uPA was negatively correlated with CD8+ T cells infiltration (R = -0.38, P = 0.026; Figures 1E, F), indicating that highly expression of uPA was associated with poorer CD8+ T cells infiltration in patients with prostate cancer.