PLAU and neoplasm: Compared with isotype control group, depletion of CD8+ T cells with anti-CD8α antibodies accelerated tumor progression in both WT and uPA–/– mice (WT- Isotype: 388.70 ± 163.53 mm3; WT- Anti-CD8α: 659.83 ± 329.32 mm3; uPA–/– Isotype: 65.39 ± 34.54 mm3; uPA–/– Anti-CD8α: 256.24 ± 109.25 mm3; Figures 5B, C), which underscored the centrality of CD8+ T cells in antitumor immunity.