TRPV2 and Alzheimer disease: Furthermore, increased TRPV2 palmitoylation in the brains of AD mice inhibits Aβ phagocytosis in microglia, accompanied by a decrease in their phosphorylation levels, suggesting that the tyrosine phosphorylation cycle and the cysteine palmitoylation cycle have opposing effects on transient receptor potential vanilloid 2 (TRPV2) channel-mediated Aβ phagocytosis in microglia (172).