Notably, Zdhhc7 KO mice exhibited significant hyperglycemia and glucose intolerance phenotypes, a finding that not only confirms the central role of the ZDHHC7-Glut4 pathway in glucose metabolism regulation but also suggests that the defective palmitoylation of Glut4 may be an important link in the pathogenesis of diabetic hyperglycemia (232). This evidence concerns the gene ZDHHC7 and Glucose intolerance.