Cerebroside (CEGI) reduces Aβ deposition and ameliorates cognitive dysfunction in APPswe/PS1dE9 AD model mice by decreasing the level of PSD-95 palmitoylation while up-regulating the expression of synaptic proteins, such as NR2B, SYT1, and PSD-95, in the frontal cortex (176). Here, DLG4 is linked to Alzheimer disease.