Conversely, an anaplastic-thyroid-cancer (ATC) compendium uncovered pervasive CD8+-T-cell exhaustion (PD-1/LAG-3/TIM-3 co-expression) and M2-skewed macrophages, nominating dual PD-1+ LAG-3 blockade or macrophage-reprogramming as rational combinations for these “cold” tumours (51). This evidence concerns the gene LAG3 and neoplasm.