GSEA enrichment analysis indicated that the TLSLow group was enriched in multiple pathways related to immunosuppression and tumor progression (Figure 5F), including “HALLMARK KRAS SIGNALING UP”, “HALLMARK HYPOXIA”, “HALLMARK GLYCOLYSIS”, “HALLMARK TGF BETA SIGNALING”, and “HALLMARK NOTCH SIGNALING”. Here, KRAS is linked to neoplasm.