Interestingly, the number of interactions among epithelial tumor cells, CAFs, and immune cells (such as CD4 memory T cells, Macro_Mono, activated B cells, etc.)also increased significantly within the TME of the TLShigh group, suggesting that tumor cells and matrix components may try to establish more connections with immune cells in an immune-active environment to regulate their own behavior. The gene discussed is CD4; the disease is neoplasm.