ZC3H13 and esophageal squamous cell carcinoma: WB analysis of CCL5 and CXCL8 expression in ESCC cells showed that when ZC3H13-shrna inhibited ZC3H13 expression, CCL5 and CXCL8 expression was down-regulated, and when ZC3H13-OE promoted ZC3H13 expression, CCL5 and CXCL8 expression was up-regulated (Figure 2A).