Previous studies, particularly in hepatocellular carcinoma (HCC), have demonstrated the inhibition of M2 polarization of THP-1 M0 macrophages through the CCL5-CCR5 signaling pathway using Maraviroc (MVC), mediated by the STAT3-SOCS3 signaling pathway (21). The gene discussed is SOCS3; the disease is hepatocellular carcinoma.