In the present study, we confirmed the critical role of PSPC1 in gastric cancer progression by functional experiments, which is consistent with its report of promoting malignant phenotypes in other tumors (37–41), suggesting that PSPC1 may be involved in gastric cancer development by influencing the LLPS process, providing a theoretical basis for the development of targeted therapeutic strategies against PSPC1. Here, PSPC1 is linked to gastric cancer.