EZH2, as an epigenetic regulator, affects gene expression by regulating histone methylation, and promotes tumor growth, metastasis, and drug resistance in a variety of malignancies (42, 43).In this study, we confirmed that EZH2 is highly expressed in gastric cancer, and CERES algorithm analysis showed that several gastric cancer cell lines were highly dependent on EZH2, supporting its potential as a therapeutic target. This evidence concerns the gene EZH2 and gastric cancer.