AIH-PSC overlap syndrome diagnosis requires integrating laboratory (elevated AST/ALT, γ-globulin, IgG, and GGT), serologic (negative AMA), histopathologic (interface hepatitis), and cholangiographic data (biliary strictures with intervening dilations), often in the context of a compatible clinical presentation [19]. The gene discussed is GPT; the disease is pancreatic serous cystadenoma.