POLE and neoplasm: The good prognosis of POLEmut tumors is maintained even in the presence of properties otherwise considered as high-risk such as substantial lymph vascular space invasion (LVSI), TP53 mutation, high tumor grade, or aggressive histology (7, 8).Therefore, recent treatment recommendations insistently favor de-escalation of adjuvant treatment in early POLE-mutated EC irrespective of other additional risk factors.