IDH2 and central nervous system cancer: The age of MGMT unmethylated patients was higher than that of the methylated group in the IDH wild-type cohort (67 vs. 59 years, p = 0.021), whereas there was no statistically significant difference in the mutant group (Table 1), Among the 22 IDH-mutant gliomas, 1p19q status was available for 12 cases: 3 with intact 1p/19q, 8 with 1p/19q codeletion, and 1 with isolated 19q deletion.