The high-risk group showed activation of complement and coagulation cascades, olfactory transduction, and ribosome pathways (FDR<0.25, ranked by |NES|), while the low-risk group was enriched in amyotrophic lateral sclerosis, FcγR-mediated phagocytosis, and focal adhesion pathways (Figure 6C). Here, FCGR2A is linked to amyotrophic lateral sclerosis.