Potentially pathogenic variants in 8 Cancer Gene Census germline genes: BRCA1, BRCA2, ERCC4, EXT1, HNF1 A, PTCH1, SMARCB1 and TP53. Variants in TP53, BRCA1, and BRCA2 likely led to early onset of disease (in 14%). Here, BRCA2 is linked to cancer.