In NSCLC, CDKN1A (p21) and TIMP3, which act as tumor suppressor genes, can be demethylated by overexpressed ALKBH5 and recognized by IGF2BPs, promoting the apoptosis, proliferation, and tumorigenesis of NSCLC cell in vivo and in vitro (62). The gene discussed is CDKN1A; the disease is non-small cell lung carcinoma.