YTHDF1 and neoplasm: Furthermore, YTHDF1 silence can increase MHCII expression and interleukin-12 (IL-12) secretion, promoting the infiltration of CD4+ and CD8+ T cells and mediating overexpression of IFN-γ receptor 1 as well as JAK/STAT1 signaling pathway, thus recovering sensitivity to anti-tumor immunity in GC (183).