(173) have developed a photosensitive and dual-targeting nanoparticle system (M.RGD@Cr-CTS-siYTHDF1NPs) capable of delivering small interfering RNA YTHDF1 for silencing YTHDF1, leading to a pro-immunogenic tumor microenvironment (TME) state and the inhibition of immunosuppressive tumor immune microenvironment (TIME). This evidence concerns the gene YTHDF1 and neoplasm.