(68) found that a high level of ALKBH5 impels the stability of MAP3K8 mRNA in an m6A-YTHDF2-dependent manner and upregulates MAP3K8 expression to promote the activation of IL-8 via the JNK and ERK pathways, thus recruiting PD-L1+ macrophages to participate in shaping the immunosuppressant microenvironment of HCC. This evidence concerns the gene CD274 and hepatocellular carcinoma.