PRMT5 and obesity due to melanocortin 4 receptor deficiency: However, the m6A demethylase, often referred to as “erasers”, comprises the alpha-ketoglutarate-dependent dioxygenase alkB homolog 1-8 (ALKBH1-8), fat mass and obesity-related proteins (FTO), and protein arginine methyltransferase 5 (PRMT5) (12, 13).