ALKBH5 and non-small cell lung carcinoma: Furthermore, the ALKBH5 depletion increases m6A modification in the 3’UTR of XBP1 mRNA, and enhances its stabilization in an IGF2BP3-dependent way, activating the IL-6-JAK-STAT3 signaling pathway to promote the proliferation, migration, and invasion of NSCLC cells (85).