In non-alcoholic steatohepatitis-associated HCC (NASH-HCC), YTHDF1 was targeted by lipid nanoparticles (LNPs)-encapsulated small-interfering YTHDF1, which can promote antitumor immunity by suppressing EZH2-IL-6 axis (175). Here, YTHDF1 is linked to hepatocellular carcinoma.