The upregulated ALKBH5 demethylates m6A modification of DDX58 mRNA, which suppresses the maturity of DDX58 mRNA by preventing HNRNPC binding to its m6A sites, thus promoting HNSCC progression through the IKKε/TBK1/IRF3 pathway (64). Here, RIGI is linked to head and neck squamous cell carcinoma.