In the mechanism, m6A modification of SAMD7, SOX2, and MYC is demethylated by ALKBH5 and subsequently recognized by YTHDF2, resulting in upregulated expression of SAMD7, SOX2, and MYC, which strengthen LKB1-regulated cell proliferation, colony formation, and migration of KRAS-mutated lung cancer cells (35). Here, ALKBH5 is linked to lung cancer.