In this mechanism, high-level METTL3 and low-level ALKBH5 contribute to enriched m6A modification in ITGA6 transcripts, promoting the translation of ITGA6 mRNA mediated by YTHDF1 and YTHDF3 proteins, which results in facilitating BLCA progression (74). Here, ITGA6 is linked to bladder transitional cell carcinoma.