YTHDF1 and colorectal carcinoma: A vesicle-like nanoparticles (VNPs)-encapsulated YTHDF1-siRNA (VNPs-siYTHDF1) was utilized to target YTHDF1, enhancing anti-PD1 efficacy in MC38 (MSI-H-CRC) and overcoming anti-PD1 resistance in CT26 (MSS-CRC) (174).