↓FBG, TC, TG, glycated hemoglobin↑BW, fasting insulin↓cardiac dysfunction, cardiac hypertrophy, interstitial fibrosis↓myocardial oxidative stress (↓MDA, 4-HNE, ROS, Nox2, Nox4)↓myocardial NF-κB, p65, IL-1β, IL-6, TNF-α, VCAM-1. This evidence concerns the gene NOX4 and cardiac hypertrophy.