In Alzheimer's disease models, this pathway has been shown to attenuate Aβ‐induced neurotoxicity and reduce tau hyperphosphorylation, whereas in our SCI model it mediates bilirubin's anti‐inflammatory effects through SOCS3 induction, a critical suppressor of pro‐inflammatory pathways. Here, SOCS3 is linked to early-onset autosomal dominant Alzheimer disease.