A previous study showed that administering CNTF cytokines to both genetically obese mice and diet‐induced obese mice resulted in weight loss, while CNTF variants with impaired interaction between Interleukin‐6 receptor subunit beta and leukemia inhibitory factor receptor (LIFR) lacked activity, suggesting that CNTF has an anti‐obesity effect, which may be mediated through the activation of gp130 and LIFR (Gloaguen et al. Here, CNTF is linked to obesity due to melanocortin 4 receptor deficiency.