APP and Alzheimer disease: 2011). This subunit plays a crucial role in both classical and trans‐signaling pathways of IL‐6. In trans‐signaling, IL‐6 receptor (IL‐6R) is released from the cell surface, resulting in a soluble form of IL‐6R (sIL‐6R). The complex formed by IL‐6 and sIL‐6R enhances the expression of interleukin‐6 receptor subunit beta and promotes pro‐inflammatory responses (Rose‐John et al. 2023). Studies have shown that the trans‐signaling of IL‐6 can stimulate the transcription of amyloid precursor proteins and participate in neurodegenerative diseases such as AD (Rothaug et al. 2016).