In order to explore whether the development of obesity and AD are related to interleukin‐6 receptor subunit beta and IL‐6 cytokine family expression levels, we employed ELISA to quantify the levels of interleukin‐6 receptor subunit beta, IL‐6, and OSM in serum and hippocampal tissue from the control group, obesity group, and AD group. The gene discussed is IL6; the disease is obesity disorder.