Specifically, higher levels of CD39+ CD8br AC, CD8 on NKT, CD8dim %T cells, HLA‐DR on HLA‐DR+ NK, IgD+ CD24+ %lymphocytes, IgD+ CD24+ AC, and naïve CD4+ %CD4+ cells were associated with an increased risk of SLE. This evidence concerns the gene CD8A and systemic lupus erythematosus.