MMP3 and fibromyalgia: By using large-scale genome-wide association study (GWAS) data and genetic variations strongly associated with exposure factors, MR infers the potential causal relationship between exposure and outcome, effectively reducing the influence of confounding factors, reverse causality, and the limitations of observational studies.[10] This study first uses 2-sample MR to analyze the causal association between MMP-3 levels and fibromyalgia, aiming to provide genetic evidence for the pathogenesis and potential therapeutic targets of fibromyalgia.