The limitations of this study include: the sample is limited to European populations, and extrapolation to other races requires caution; the GWAS data of fibromyalgia did not provide gender/age stratification; residual pleiotropy cannot be completely excluded, although the intercept test showed no significant horizontal pleiotropy; and genetic variations in MMP-3 may only explain part of the variation in serum levels, with the possibility of residual weak IV bias. This evidence concerns the gene MMP3 and fibromyalgia.