For instance, several studies have reported a correlation between high YTHDF3 expression and immune cell infiltration, including CD8 + T cells and Tregs, in the tumor microenvironment.[35,36] CD45RA+ resting Tregs represent a subset of Treg cells in a naïve or resting state, and are characterized by strong immunosuppressive and tissue-protective functions during the early stages of inflammation. The gene discussed is YTHDF3; the disease is neoplasm.