Specifically, 19 CpG sites showed strong colocalization with cholelithiasis, including DMPK (cg17499826, cg16686429), LIAS (cg15128470), HEBP1 (cg12479139), PPIF (cg03648155), MRPS21 (cg07843065), SLC25A33 (cg13688474, cg09058554), PRELID1 (cg18824775), RAB24 (cg18824775), DLD (cg17593404), PNKD (cg13835894, cg01329789, cg22712983, cg26786924, cg05991184, cg18259342, cg04880052), and MCCD1 (cg02481669). This evidence concerns the gene HEBP1 and cholelithiasis.