Similarly, methylation at cg12479139 in HEBP1 (OR = 0.839, 95% CI = 0.768–0.916) and at cg05991184 in PNKD (OR = 0.766, 95% CI = 0.693–0.847) were also protective factors against cholelithiasis (Table 3). This evidence concerns the gene HEBP1 and cholelithiasis.