Additionally, increased gene expression of LIAS (OR = 1.10, 95% CI = 1.06–1.14) and PNKD (OR = 1.12, 95% CI = 1.09–1.15) in blood was associated with an increased risk of cholelithiasis, while higher expression of HEBP1 (OR = 0.92, 95% CI = 0.89–0.96) was associated with a reduced risk of cholelithiasis. Here, HEBP1 is linked to cholelithiasis.