In a proteome-wide MR study of cirrhosis, Xiao et al likewise reported protective effects of complement and iron-metabolism proteins (e.g., SERPINA1, NCAN) while systematically evaluating potential off-target consequences.[34] Therapeutic regimens that bolster C3b or TF, while attenuating LAG-3-dependent cytokine release, may therefore restore immune–redox*** equilibrium. This evidence concerns the gene TF and Cirrhosis.