In humans and, to a lesser extent, in mice, CD4 Treg and CD8 Treg are also characterized by lower levels of CD127 compared to effector T cell.[44] In our study CD127 on CD28 + CD45RA + CD8 + T cells expressing high levels of CD127 promoted the development of MI, consistent with previous findings. The gene discussed is CD8A; the disease is myocardial infarction.