CD40-CD40L interaction is the link between immunity, CD40-CD40L interacts as a nexus between immune, inflammatory and coagulation states and is overexpressed in patients with atherosclerosis-related diseases, such as stroke and CAD, and several studies have shown that inhibition of CD40 or CD40L significantly reduces atherosclerosis in hyperlipidaemic mice.[79–81] This contradicts our findings. This evidence concerns the gene CD40 and atherosclerosis.