The Osaka prognostic score, based on ALB, CRP, and total lymphocyte count, predicted OS with a C-index of 0.68.[21] The BAN score, incorporating BMI, ALB, and neutrophil-to-lymphocyte ratio, was an independent prognostic factor for DFS and OS.[27] These findings highlight the importance of integrating multiple parameters for more accurate prognostic assessment in ESCC patients undergoing CCRT. Here, ALB is linked to esophageal squamous cell carcinoma.