However, excessive FT3/FT4 can inhibit the secretion of TSH by the pituitary gland, further reducing the synthesis of thyroid hormones and forming a self-regulating closed loop.[3,4] Clinically, it manifests as fatigue, palpitations, tremors, irritability, exophthalmos, and thyroid enlargement, significantly affecting the patient’s physical health and quality of life.[5] Studies indicate that 0.1% to 2.5% of the population generally has hyperthyroidism, with Graves’ disease being the most common, accounting for approximately 80% of hyperthyroidism cases. This evidence concerns the gene TG and hyperthyroidism.