ESR1 and cancer: And were closely related to breast cancer, cancer, osteoporosis, and other diseases.[23] In addition, estrogen receptors and NF-κB inhibit each other in a cell type-specific manner, thereby reducing NF-κB activity and inhibiting its mediated IL6 transcription.[24] IL6 is an oncogenic inflammatory factor that plays an important role in chronic tumor inflammation and maintaining the tumor microenvironment.