MVMR analysis showed that even after adjusting for cholelithiasis and TG, the causal effect of CeD on AP (ORIVW = 1.05, 95% CI = 1.03–1.08, P < .001) and CP (ORIVW = 1.07, 95% CI = 1.03–1.10, P < .001) remained significant (Fig. 6). This evidence concerns the gene DHCR7-DT and cholelithiasis.