The MVMR result suggested the causal effects of CeD on AP (ORIVW = 1.05, 95% CI = 1.03–1.08, P < .001) and CP (ORIVW = 1.07, 95% CI = 1.03–1.10, P < .001) remain significant even after adjusting for cholelithiasis and TG. This evidence concerns the gene CP and cholelithiasis.