EPHB2 and colorectal carcinoma: EPHB2, a member of the Eph receptor family, plays a crucial role in cell-cell signaling and has been implicated in various cancers, including CRC.[18] TOP2A, encoding topoisomerase II alpha, is essential for DNA replication and repair and has been linked to both SLE and CRC.[19,20] Our study confirmed that both EPHB2 and TOP2A are significantly overexpressed in SLE and CRC patients, suggesting their potential role as bridges in the inflammatory and tumorigenic processes.