For TOP2A, poisons such as etoposide and doxorubicin stabilize DNA cleavage complexes for antiproliferative activity,[52,53] while catalytic inhibitors like ICRF193[54] and TSC24[55] block ATPase function with less genotoxicity, suitable for SLE’s DNA repair vulnerabilities. Here, DNAH8 is linked to systemic lupus erythematosus.