EPHB2, a member of the Eph receptor family, plays a crucial role in cell-cell signaling and has been implicated in various cancers, including CRC.[18] TOP2A, encoding topoisomerase II alpha, is essential for DNA replication and repair and has been linked to both SLE and CRC.[19,20] Our study confirmed that both EPHB2 and TOP2A are significantly overexpressed in SLE and CRC patients, suggesting their potential role as bridges in the inflammatory and tumorigenic processes. This evidence concerns the gene EPHB2 and systemic lupus erythematosus.