CD14 and rheumatoid arthritis: It was found that the percentage of CD14+CD16+ cells in the peripheral blood of PSA patients was higher than that of healthy controls, and the expression level of CD16+ in PSA was positively correlated with the degree of bone erosion.[41] In further studies by comparing the bone resorption capacity of CD14+CD16+ and CD14+CD16− monocytes in RA patients, it was shown that CD14+CD16− monocytes dominated the bone resorption process in RA patients.