These correlations were moderate to strong as observed in the TCGA-COAD RNA-seq cohort (CD274 vs. PTGS2, R = 0.48; CD8A vs. CD274, R = 0.67) (Fig. 1b) and similar when validated in the E-MTAB-12,862 cohort, comprising over 1,000 CRC tumor samples (CD274 vs. PTGS2, R = 0.47; CD8A vs. CD274, R = 0.61) (Fig. 1c). This evidence concerns the gene CD8A and colorectal carcinoma.