To evaluate the transcriptomic associations observed in public datasets that also manifest at the protein level, we next analyzed a clinically annotated, IHC-based internal CRC cohort (n = 320, female cohort) focusing on PD-L1, COX-2, 15-PGDH, and T-cell markers (CD3, CD4, CD8). This evidence concerns the gene CD274 and colorectal carcinoma.