Cirrhosis (HR = 1.500, p = 0.003), portal hypertension (HR = 1.200, p = 0.024), AFP > 20 ng/mL (HR = 1.500, p = 0.002), re-recurrence after rHCC (HR = 1.300, p = 0.035), tumor diameter > 3 cm (HR = 3.200, p < 0.001), multiple tumors (HR = 2.200, p < 0.001), subcapsular tumor (HR = 1.100, p = 0.056), and recurrence within 1 year (HR = 2.200, p < 0.001) were independent risk factor for OS. The gene discussed is AFP; the disease is portal hypertension.