To achieve this, a new vaccinia virus co-expressing human IL-7 and human IL-12 (hIL7/hIL12-VV) was engineered, and its efficacy was assessed in immunocompromised mice bearing human HCT 116 colon tumors, U87 glioblastoma, or Detroit 562 head and neck tumors [30]. Here, IL7 is linked to glioblastoma.