A SINV co-expressing IL-7 plus IL-12 (SINV-IL7/IL12) further enhanced tumor suppression compared to SINV-IL7 or SINV-IL12, with SINV-IL7/IL12 achieved 80% long-term survivors in an intracranial U-87MG GBM model (Table 1). The gene discussed is IL7; the disease is glioblastoma.