GPHN and Epileptic encephalopathy: After showing that SDII is required for Geph filament formation, LLPS and receptor clustering, we asked whether we can disclose the mechanistic basis of epileptic encephalopathy in previously identified pathogenic variants of Geph, GephG375D and GephD422N, which are both located within SDII and in case of GephG375D shows a strong impairment in LLPS formation14,31,33.