RNA-seq and transcriptomic analysis revealed that Auranofin and the combination with COJEC significantly downregulated pathways associated with tumor malignancy and metastatic capacity, such as MTORC1 signaling, glycolysis, Notch signaling, KRAS signaling, WNT-β catenin signaling, hypoxia, angiogenesis, IL-6/JAK/STAT3 signaling, and epithelial-to-mesenchymal transition (Fig. 6C). Here, STAT3 is linked to neoplasm.