Compared with those in Gpr15+/+ mice, DSS treatment resulted in milder colonic inflammation in Tg(hGPR15) mice, characterized by less weight loss, lower DAI scores, minimal colon shortening, and reduced histopathological and endoscopic scores (Fig. 8b, d, f, h and Supplementary Fig. 13c). The gene discussed is GPR15; the disease is inflammation.