SOD1 and amyotrophic lateral sclerosis: Unexpectedly, abundance map scores did not correlate with SOD1 protein-abundance measurements in people with SOD1-ALS despite showing strong positive correlation with mouse protein half-life35,104; low SOD1 protein half-life has been attributed to increased chaperone-assisted autophagy, leading to chaperone exhaustion, higher levels of misfolded SOD1, and ALS onset.105