Since (i) regulation of translation initiation is a crucial mechanism for gene expression, dynamically regulating protein synthesis and thereby contributing to the determination of the cellular phenotype [60,61], and (ii) our results demonstrate that the HK2-SOX10 5′UTR RNA-protein interaction is involved in cancer-relevant processes such as the ability of melanoma cells to proliferate and form colonies, further research is needed to unravel the factors involved in the regulation of SOX10 mRNA translation by HK2. This evidence concerns the gene HK2 and melanoma.