The results revealed that, compared to the BPH-1 cell line, the mRNA levels of KIF14, KIF11, CENPE, KIF15, KIFC2, KIF18B, and KIFC1 were significantly upregulated in PCa cell lines (LNCaP and DU145), whereas ACTC1 expression was markedly downregulated. The gene discussed is ACTC1; the disease is posterior cortical atrophy.