ACTC1 and Familial prostate cancer: Univariate Cox regression analysis identified 8 MPRGs significantly associated with BCR in prostate cancer, including kinesin family member C2 (KIFC2), kinesin family member C1 (KIFC1), kinesin family member 18B (KIF18B), kinesin family 14 (KIF14), kinesin family 11 (KIF11), centromere protein E (CENPE), actin alpha cardiac muscle 1 (ACTC1), and kinesin family 15 (KIF15) (Fig 1E).