In the GFPG-H group, PI3K, p-AKT/AKT, and Bcl-2 levels were significantly higher (P < 0.05, P < 0.01, P < 0.001), while GSK-3β, caspase-3, and Bax expression was significantly lower (P < 0.05, P < 0.001) compared to the ANIT-induced cholestasis group. The gene discussed is BCL2; the disease is cholestasis.