HLA-G and colorectal carcinoma: HLADR and b2 microglobulin increased and we found potentiated activation and cytotoxic effects when coculturing NK cells with treated tumour cells In CRC/PBMC cocultures, increased gene expression of pro-immune cytokines including IL-2, IFN-γ and TNF-α was observed in cases where CRC cells had been pre-treated with NUC-3373.