CD274 and neoplasm: To address these seemingly paradoxical results of pro-immune (i.e., DAMP release, more potent cytokine induction, increased NK activation, and NK-mediated cytotoxicity) and anti-immune (i.e., increased PD-L1 mRNA and surface protein) readouts, a series of further coculture experiments were performed with PBMCs to determine whether NUC-3373 can promote lymphocyte mediated tumour cell death.